Epigallocatechingallat – Therapie

Aus Studienergebnissen geht hervor, dass es sich beim Epigallocatechingallat um eine der vielversprechendsten gesundheitsfördernden Substanzen handelt.

Epigallocatechingallat (EGCG) in der Therapie:

• Adipositas [1-4]
• Bösartige Neubildung der Prostata (Prostatakarzinom/Prostatakrebs) [5, 6]
• Bösartige Neubildung der Brustdrüse (Mammakarzinom/Brustkrebs) [7]
• Diabetes mellitus Typ 2 [8, 9]
• Gestationsdiabetes (Schwangerschaftsdiabetes) [10]
• Hypercholesterinämie [11]
• Kardiovaskuläre Erkrankungen (Herz- und Gefäßerkrankungen) [12-16]
• Kolorektales Karzinom (Darmkrebs) [17]
• Neurokognitive Erkrankungen [18, 19]
• Primäres Weitwinkelglaukom [20]
• Staphylokokkeninfektion [21]
• Xerosis cutis (Xerodermie/Trockene Haut) [22]

Literatur

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4. Casanova E, Salvadó J, Crescenti A, Gibert-Ramos A. Epigallocatechin Gallate Modulates Muscle Homeostasis in Type 2 Diabetes and Obesity by Targeting Energetic and Redox Pathways: A Narrative Review. Int J Mol Sci. 2019 Jan 27;20(3):532.
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10. Zhang H, Su S, Yu X, Li Y. Dietary epigallocatechin 3-gallate supplement improves maternal and neonatal treatment outcome of gestational diabetes mellitus: a double-blind randomised controlled trial. J Hum Nutr Diet. 2017 Dec;30(6):753-758.
11. Samavat H, Newman AR, Wang R, Yuan JM, Wu AH, Kurzer MS. Effects of green tea catechin extract on serum lipids in postmenopausal women: a randomized, placebo-controlled clinical trial. Am J Clin Nutr. 2016 Dec;104(6):1671-1682.
12. Khan N, Mukhtar H. Tea Polyphenols in Promotion of Human Health. Nutrients. 2018 Dec 25;11(1):39. doi: 10.3390/nu11010039.
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14. Chowdhury A, Sarkar J, Chakraborti T, Pramanik PK, Chakraborti S. Protective role of epigallocatechin-3-gallate in health and disease: A perspective. Biomed Pharmacother. 2016 Mar;78:50-59.
15. Chatree S, Sitticharoon C, Maikaew P, Pongwattanapakin K, Keadkraichaiwat I, Churintaraphan M, Sripong C, Sririwichitchai R, Tapechum S. Epigallocatechin gallate decreases plasma triglyceride, blood pressure, and serum kisspeptin in obese human subjects. Exp Biol Med (Maywood). 2021 Jan;246(2):163-176.
16. Bazyar H, Hosseini SA, Saradar S, Mombaini D, Allivand M, Labibzadeh M, Alipour M. Effects of epigallocatechin-3-gallate of Camellia sinensis leaves on blood pressure, lipid profile, atherogenic index of plasma and some inflammatory and antioxidant markers in type 2 diabetes mellitus patients: a clinical trial. J Complement Integr Med. 2020 Dec 25;18(2):405-411.
17. Hoensch H, Groh B, Edler L, Kirch W. Prospective cohort comparison of flavonoid treatment in patients with resected colorectal cancer to prevent recurrence. World J Gastroenterol. 2008 Apr 14;14(14):2187-93.
18. Fukutomi R, Ohishi T, Koyama Y, Pervin M, Nakamura Y, Isemura M. Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases. Molecules. 2021 Jan 14;26(2):415.
19. Afzal O, Dalhat MH, Altamimi ASA, Rasool R, Alzarea SI, Almalki WH, Murtaza BN, Iftikhar S, Nadeem S, Nadeem MS, Kazmi I. Green Tea Catechins Attenuate Neurodegenerative Diseases and Cognitive Deficits. Molecules. 2022 Nov 6;27(21):7604.
20. Falsini B, Marangoni D, Salgarello T, Stifano G, Montrone L, Di Landro S, Guccione L, Balestrazzi E, Colotto A. Effect of epigallocatechin-gallate on inner retinal function in ocular hypertension and glaucoma: a short-term study by pattern electroretinogram. Graefes Arch Clin Exp Ophthalmol. 2009 Sep;247(9):1223-33.
21. Yamada H, Tateishi M, Harada K, Ohashi T, Shimizu T, Atsumi T, Komagata Y, Iijima H, Komiyama K, Watanabe H, Hara Y, Ohashi K: A randomized clinical study of tea catechin inhalation effects on methicillin-resistant Staphylococcus aureus in disabled elderly patients. J Am Med Dir Assoc. 2006 Feb;7(2):79-83.
22. Puch F, Samson-Villeger S, Guyonnet D, Blachon JL, Rawlings AV, Lassel T. Consumption of functional fermented milk containing borage oil, green tea and vitamin E enhances skin barrier function. Exp Dermatol. 2008 Aug;17(8):668-74.