Quercetin – Therapie

Quercetin ist eines der wichtigsten und am genauesten erforschten Bioflavonoide mit antioxidativen, antiinflammatorischen (antientzündlichen), antiproliferativen, antikanzerogenen (krebshemmenden), antidiabetischen und antiviralen Eigenschaften. Daher gilt der Phytonährstoff als vielversprechend für den therapeutischen Einsatz bei einer Vielzahl von verschiedenen Erkrankungen, darunter Hypertonie (Bluthochdruck), Atherosklerose (Arteriosklerose/Arterienverkalkung), Infektionskrankheiten, Diabetes mellitus und Diabeteskomplikationen, Asthma bronchiale, Polyzystisches-Ovar-Syndrom (PCO-Syndrom), Tumorerkrankungen, chronisch entzündliche Darmerkrankungen (CED) und Morbus Alzheimer [1-4].

Quercetin in der Therapie:

• Allergien [5, 6]
• COVID [7]
• Dyslipidämie (Fettstoffwechselstörungen) [8, 9]
• Hypertonie (Bluthochdruck) [10-12]
• Varizen (Krampfadern) [13]
• Muskelverletzungen [14]
• Rheumatoide Arthritis [15]
• Polyzystisches-Ovar-Syndrom (PCO-Syndrom) [16, 17]

Literatur

1. Batiha GE, Beshbishy AM, Ikram M, Mulla ZS, El-Hack MEA, Taha AE, Algammal AM, Elewa YHA. The pharmacological activity, biochemical properties, and pharmacokinetics of the major natural polyphenolic flavonoid: quercetin. Foods. 2020;23;9(3):374.
2. Ulusoy HG, Sanlier N. A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities. Crit Rev Food Sci Nutr. 2019:1-14.
3. Anand David AV, Arulmoli R, Parasuraman S. Overviews of biological importance of quercetin: a bioactive flavonoid. Pharmacogn Rev. 2016;10(20):84-89.
4. Russo M, Spagnuolo C, Tedesco I, Bilotto S, Russo GL. The flavonoid quercetin in disease prevention and therapy: facts and fancies. Biochem Pharmacol. 2012;83(1):6-15.
5. Yamada S, Shirai M, Inaba Y, Takara T. Effects of repeated oral intake of a quercetin-containing supplement on allergic reaction: a randomized, placebo-controlled, double-blind parallel-group study. Eur Rev Med Pharmacol Sci. 2022 Jun;26(12):4331-4345.
6. Mlcek J, Jurikova T, Skrovankova S, Sochor J. Quercetin and its anti-allergic immune response. Molecules. 2016;21(5):E623.
7. Shohan M, Nashibi R, Mahmoudian-Sani MR, Abolnezhadian F, Ghafourian M, Alavi SM, Sharhani A, Khodadadi A. The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial. Eur J Pharmacol. 2022 Jan 5;914:174615.
8. Huang H, Liao D, Dong Y, Pu R. Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysis. Nutr Rev. 2020 Aug 1;78(8):615-626.
9. Tabrizi R, Tamtaji OR, Mirhosseini N, Lankarani KB, Akbari M, Heydari ST, Dadgostar E, Asemi Z. The effects of quercetin supplementation on lipid profiles and inflammatory markers among patients with metabolic syndrome and related disorders: A systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019:1-14.
10. Popiolek-Kalisz J, Fornal E. The Effects of Quercetin Supplementation on Blood Pressure - Meta-Analysis. Curr Probl Cardiol. 2022 Nov;47(11):101350.
11. Serban MC, Sahebkar A, Zanchetti A, Mikhailidis DP, Howard G, Antal D, Andrica F, Ahmed A, Aronow WS, Muntner P, Lip GY, Graham I, Wong N, Rysz J, Banach M; Lipid and Blood Pressure Meta‐analysis Collaboration (LBPMC) Group. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Am Heart Assoc. 2016 Jul 12;5(7):e002713.
12. Edwards RL, Lyon T, Litwin SE, Rabovsky A, Symons JD, Jalili T. Quercetin reduces blood pressure in hypertensive subjects. J Nutr. 2007 Nov;137(11):2405-11.
13. Stücker M, Debus ES, Hoffmann J, Jünger M, Kröger K, Mumme A, Ramelet AA, Rabe E. Konsensuspapier zur symptomorientierten Therapie der chronischen Venenerkrankungen. J Dtsch Dermatol Ges 2016;14(6):575-584.
14. Bazzucchi I, Patrizio F, Ceci R, Duranti G, Sgrò P, Sabatini S, Di Luigi L, Sacchetti M, Felici F. The Effects of Quercetin Supplementation on Eccentric Exercise-Induced Muscle Damage. Nutrients. 2019 Jan 21;11(1):205.
15. Bae SC, Jung WJ, Lee EJ, Yu R, Sung MK. Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients. J Am Coll Nutr. 2009 Feb;28(1):56-62.
16. Vaez S, Parivr K, Amidi F, Rudbari NH, Moini A, Amini N. Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial. Am J Reprod Immunol. 2023 Mar;89(3):e13644.
17. Pourteymour Fard Tabrizi F, Hajizadeh-Sharafabad F, Vaezi M, Jafari-Vayghan H, Alizadeh M, Maleki V. Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review. J Ovarian Res. 2020 Jan 31;13(1):11.