Resveratrol – Prävention

Die antioxidativen, antiinflammatorischen (antientzündlichen) und zellregulatorischen Eigenschaften von Resveratrol können möglicherweise zu präventiven Wirkungen hinsichtlich verschiedener Erkrankungen beitragen, darunter kardiovaskuläre (Herz-Kreislauf-) Erkrankungen, Tumorerkrankungen, Diabetes mellitus und Morbus Alzheimer [1].

Resveratrol in der Prävention:

• Alzheimer-Demenz [2-5]
• Atherosklerose (Arteriosklerose; Arterienverkalkung) [6, 7]
• Diabetes mellitus Typ 2 [8, 15]
• Hypercholesterinämie [9]
• Hypertonie (Bluthochdruck) [9]
• Kardiovaskuläre Erkrankungen (Herz- und Gefäßkrankheiten) [9-12]
• Metabolisches Syndrom/Übergewicht [13, 14]
• „Non-communicable diseases“ (NCD) (Nicht-übertragbare Erkrankungen) [15]
• Osteopathien (Knochenerkrankungen) [16-18]
• Renale Funktionsstörung (die Nieren betreffend) [19]
• Senilität (Altersschwäche) [20]

Literatur

1. Zhang LX, Li CX, Kakar MU, Khan MS, Wu PF, Amir RM, Dai DF, Naveed M, Li QY, Saeed M, Shen JQ, Rajput SA, Li JH. Resveratrol (RV): A pharmacological review and call for further research. Biomed Pharmacother. 2021 Nov;143:112164.
2. Buglio DS, Marton LT, Laurindo LF, Guiguer EL, Araújo AC, Buchaim RL, Goulart RA, Rubira CJ, Barbalho SM. The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review. J Med Food. 2022 Aug;25(8):797-806.
3. Thaung Zaw JJ, Howe PR, Wong RH. Long-term effects of resveratrol on cognition, cerebrovascular function and cardio-metabolic markers in postmenopausal women: A 24-month randomised, double-blind, placebo-controlled, crossover study. Clin Nutr. 2021 Mar;40(3):820-829.
4. Sawda C, Moussa C, Turner RS. Resveratrol for Alzheimer's disease. Ann N Y Acad Sci. 2017 Sep;1403(1):142-149.
5. Pasinetti GM, Wang J, Ho L, Zhao W, Dubner L. Roles of resveratrol and other grape-derived polyphenols in Alzheimer's disease prevention and treatment. Biochim Biophys Acta. 2015 Jun;1852(6):1202-8.
6. Agarwal B, Campen MJ, Channell MM, Wherry SJ, Varamini B, Davis JG, Baur JA, Smoliga JM. Resveratrol for primary prevention of atherosclerosis: clinical trial evidence for improved gene expression in vascular endothelium. Int J Cardiol. 2013 Jun 5;166(1):246-8.
7. Imamura H, Yamaguchi T, Nagayama D, Saiki A, Shirai K, Tatsuno I. Resveratrol ameliorates arterial stiffness assessed by cardio-ankle vascular index in patients with type 2 diabetes mellitus. Int Heart J. 2017;58:577-583.
8. Liu K, Zhou R, Wang B, Mi MT. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr. 2014 Jun;99(6):1510-9.
9. Huang H, Chen G, Liao D, Zhu Y, Pu R, Xue X. The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials. Obes Rev. 2016 Dec;17(12):1329-1340.
10. Tomé-Carneiro J, Gonzálvez M, Larrosa M, Yáñez-Gascón MJ, García-Almagro FJ, Ruiz-Ros JA, García-Conesa MT, Tomás-Barberán FA, Espín JC. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol. 2012 Aug 1;110(3):356-63.
11. Tomé-Carneiro J, Gonzálvez M, Larrosa M, Yáñez-Gascón MJ, García-Almagro FJ, Ruiz-Ros JA, Tomás-Barberán FA, García-Conesa MT, Espín JC. Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther. 2013 Feb;27(1):37-48.
12. Gresele P, Pignatelli P, Guglielmini G, Carnevale R, Mezzasoma AM, Ghiselli A, Momi S, Violi F. Resveratrol, at concentrations attainable with moderate wine consumption, stimulates human platelet nitric oxide production. J Nutr. 2008 Sep;138(9):1602-8.
13. Fraiz GM, da Conceição AR, de Souza Vilela DL, Rocha DMUP, Bressan J, Hermsdorff HHM. Can resveratrol modulate sirtuins in obesity and related diseases? A systematic review of randomized controlled trials. Eur J Nutr. 2021 Sep;60(6):2961-2977.
14. Tabrizi R, Tamtaji OR, Lankarani KB, Akbari M, Dadgostar E, Dabbaghmanesh MH, Kolahdooz F, Shamshirian A, Momen-Heravi M, Asemi Z. The effects of resveratrol intake on weight loss: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2020;60(3):375-390.
15. Guo XF, Li JM, Tang J, Li D. Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2018;58(17):3016-3029.
16. Inchingolo AD, Inchingolo AM, Malcangi G, Avantario P, Azzollini D, Buongiorno S, Viapiano F, Campanelli M, Ciocia AM, De Leonardis N, de Ruvo E, Ferrara I, Garofoli G, Montenegro V, Netti A, Palmieri G, Mancini A, Patano A, Piras F, Marinelli G, Di Pede C, Laudadio C, Rapone B, Hazballa D, Corriero A, Fatone MC, Palermo A, Lorusso F, Scarano A, Bordea IR, Di Venere D, Inchingolo F, Dipalma G. Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review. Nutrients. 2022 Aug 26;14(17):3519.
17. Corbi G, Nobile V, Conti V, Cannavo A, Sorrenti V, Medoro A, Scapagnini G, Davinelli S. Equol and Resveratrol Improve Bone Turnover Biomarkers in Postmenopausal Women: A Clinical Trial. Int J Mol Sci. 2023 Jul 27;24(15):12063.
18. Ornstrup MJ, Harsløf T, Kjær TN, Langdahl BL, Pedersen SB. Resveratrol increases bone mineral density and bone alkaline phosphatase in obese men: a randomized placebo-controlled trial. J Clin Endocrinol Metab. 2014;99(12):4720- 29.
19. Abdollahi S, Vajdi M, Meshkini F, Vasmehjani AA, Sangsefidi ZS, Clark CCT, Soltani S. Resveratrol may mildly improve renal function in the general adult population: A systematic review and meta-analysis of randomized controlled clinical trials. Nutr Res. 2023 May;113:1-13.
20. Rabassa M, Zamora-Ros R, Urpi-Sarda M, Bandinelli S, Ferrucci L, Andres-Lacueva C, Cherubini A. Association of habitual dietary resveratrol exposure with the development of frailty in older age: the Invecchiare in Chianti study. Am J Clin Nutr. 2015 Dec;102(6):1534-42.