Melatonin – Therapie

Melatonin kann möglicherweise aufgrund seiner antioxidativen [1, 2], antiinflammatorischen (entzündungshemmenden) [3] und immunstärkenden [4, 5] Eigenschaften folgende therapeutische Wirkungen hinsichtlich verschiedener Erkrankungen aufweisen.

Melatonin in der Therapie:

  • Altersbedingte Makuladegeneration (AMD) [6, 7]
  • Autismus-Spektrum-Störungen [8, 9]
  • Depression [10-12]
  • Diabetes mellitus Typ 2 [13, 14]
  • Hypertonie (Bluthochdruck) [15, 16]
  • Insomnie (Schlafstörungen) [17, 18]
  • Jetlag [19]
  • Migräne und Clusterkopfschmerzen [20, 21]
  • Morbus Alzheimer [22]
  • Parodontitis (Erkrankung des Zahnhalteapparates) [23, 24]
  • Refluxkrankheit [25-27]
  • Reizdarmsyndrom (RDS) [28, 29]
  • Tumorerkrankungen [30-34]

Literatur

  1. Reiter RJ, Tan DX, Galano A. Melatonin: exceeding expectations. Physiology (Bethesda). 2014 Sep;29(5):325-33
  2. Chitimus DM, Popescu MR, Voiculescu SE, Panaitescu AM, Pavel B, Zagrean L, Zagrean AM. Melatonin's Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease. Biomolecules. 2020 Aug 20;10(9):1211
  3. Nabavi SM, Nabavi SF, Sureda A, Xiao J, Dehpour AR, Shirooie S, Silva AS, Baldi A, Khan H, Daglia M. Anti-inflammatory effects of Melatonin: A mechanistic review. Crit Rev Food Sci Nutr. 2019;59(sup1):S4-S16
  4. Cardinali DP, Esquifino AI, Srinivasan V, Pandi-Perumal SR. Melatonin and the immune system in aging. Neuroimmunomodulation. 2008;15(4-6):272-8
  5. Guerrero JM, Reiter RJ. Melatonin-immune system relationships. Curr Top Med Chem. 2002 Feb;2(2):167-79
  6. Mehrzadi S, Hemati K, Reiter RJ, Hosseinzadeh A. Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment. Expert Opin Ther Targets. 2020 Apr;24(4):359-378
  7. Crooke A, Huete-Toral F, Colligris B, Pintor J. The role and therapeutic potential of melatonin in age-related ocular diseases. J Pineal Res. 2017 Sep;63(2)
  8. Poudineh M, Parvin S, Omidali M, Nikzad F, Mohammadyari F, Sadeghi Poor Ranjbar F, Rasouli F, Nanbakhsh S, Olangian-Tehrani S. The Effects of Vitamin Therapy on ASD and ADHD: A Narrative Review. CNS Neurol Disord Drug Targets. 2023;22(5):711-735
  9. Giri A, Mehan S, Khan Z, Das Gupta G, Narula AS, Kalfin R. Modulation of neural circuits by melatonin in neurodegenerative and neuropsychiatric disorders. Naunyn Schmiedebergs Arch Pharmacol. 2024 Jun;397(6):3867-3895
  10. Satyanarayanan SK, Su H, Lin YW, Su KP. Circadian Rhythm and Melatonin in the Treatment of Depression. Curr Pharm Des. 2018;24(22):2549-2555
  11. Hansen MV, Danielsen AK, Hageman I, Rosenberg J, Gögenur I. The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: a systematic review and meta-analysis. Eur Neuropsychopharmacol. 2014 Nov;24(11):1719-28
  12. Kholghi G, Eskandari M, Shokouhi Qare Saadlou MS, Zarrindast MR, Vaseghi S. Night shift hormone: How does melatonin affect depression? Physiol Behav. 2022 Aug 1;252:113835
  13. Shen S, Liao Q, Wong YK, Chen X, Yang C, Xu C, Sun J, Wang J. The role of melatonin in the treatment of type 2 diabetes mellitus and Alzheimer's disease. Int J Biol Sci. 2022 Jan 1;18(3):983-994
  14. Mok JX, Ooi JH, Ng KY, Koh RY, Chye SM. A new prospective on the role of melatonin in diabetes and its complications. Horm Mol Biol Clin Investig. 2019 Nov 6;40(1):/j/hmbci.2019.40.issue-1/hmbci-2019-0036/hmbci-2019-0036.xml
  15. Baker J, Kimpinski K. Role of melatonin in blood pressure regulation: An adjunct anti-hypertensive agent. Clin Exp Pharmacol Physiol. 2018 Aug;45(8):755-766
  16. Grossman E, Laudon M, Zisapel N. Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials. Vasc Health Risk Manag. 2011;7:577-84
  17. Poza JJ, Pujol M, Ortega-Albás JJ, Romero O; Insomnia Study Group of the Spanish Sleep Society (SES). Melatonin in sleep disorders. Neurologia (Engl Ed). 2022 Sep;37(7):575-585
  18. Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W, Yu F. A review of sleep disorders and melatonin. Neurol Res. 2017 Jun;39(6):559-565
  19. Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev. 2002;(2):CD001520
  20. Zduńska A, Cegielska J, Domitrz I. The Pathogenetic Role of Melatonin in Migraine and Its Theoretic Implications for Pharmacotherapy: A Brief Overview of the Research. Nutrients. 2022 Aug 15;14(16):3335
  21. Gelfand AA, Goadsby PJ. The Role of Melatonin in the Treatment of Primary Headache Disorders. Headache. 2016 Sep;56(8):1257-66.
  22. Cardinali DP, Vigo DE, Olivar N, Vidal MF, Brusco LI. Melatonin Therapy in Patients with Alzheimer's Disease. Antioxidants (Basel). 2014 Apr 10;3(2):245-77
  23. Liu RY, Li L, Zhang ZT, Wu T, Lin S, Zhang XT. Clinical efficacy of melatonin as adjunctive therapy to non-surgical treatment of periodontitis: a systematic review and meta-analysis. Inflammopharmacology. 2022 Jun;30(3):695-704
  24. Konečná B, Chobodová P, Janko J, Baňasová L, Bábíčková J, Celec P, Tóthová Ľ. The Effect of Melatonin on Periodontitis. Int J Mol Sci. 2021 Feb 27;22(5):2390
  25. Pereira Rde S. Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole. J Pineal Res. 2006 Oct;41(3):195-200
  26. Werbach MR. Melatonin for the treatment of gastroesophageal reflux disease. Altern Ther Health Med. 2008 Jul-Aug;14(4):54-8
  27. Patrick L. Gastroesophageal reflux disease (GERD): a review of conventional and alternative treatments. Altern Med Rev. 2011 Jun;16(2):116-33
  28. Mozaffari S, Rahimi R, Abdollahi M. Implications of melatonin therapy in irritable bowel syndrome: a systematic review. Curr Pharm Des. 2010;16(33):3646-55.
  29. Siah KT, Wong RK, Ho KY. Melatonin for the treatment of irritable bowel syndrome. World J Gastroenterol. 2014 Mar 14;20(10):2492-8
  30. Ngai ZN, Chok KC, Ng KY, Koh RY, Chye SM. Potential role of melatonin in prevention and treatment of lung cancer. Horm Mol Biol Clin Investig. 2022 Jun 22;43(4):485-503
  31. Li Y, Li S, Zhou Y, Meng X, Zhang JJ, Xu DP, Li HB. Melatonin for the prevention and treatment of cancer. Oncotarget. 2017 Jun 13;8(24):39896-39921
  32. Megerian MF, Kim JS, Badreddine J, Hong SH, Ponsky LE, Shin JI, Ghayda RA. Melatonin and Prostate Cancer: Anti-tumor Roles and Therapeutic Application. Aging Dis. 2023 Jun 1;14(3):840-857
  33. Sheibani M, Seirafianpour F, Naeini AJ, Mehrzadi S. Melatonin: Current evidence on protective and therapeutic roles in gynecological diseases. Life Sci. 2024 May 1;344:122557
  34. Talib WH, Alsayed AR, Abuawad A, Daoud S, Mahmod AI. Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities. Molecules. 2021 Apr 25;26(9):2506

Autoren: Dr. med. Werner G. Gehring
Letzte Aktualisierung: 17.06.2024

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