Therapie

Spermidin zeigt verschiedene gesundheitsfördernde Eigenschaften, die zur Therapie verschiedener Erkrankungen beitragen könnten.

Spermidin in der Therapie:

• Altersabhängige Erkrankungen [1]
• COVID-Infektionen [2]
• Chronisch-entzündliche Darmerkrankungen (CED) [3]
• Dermatopathien (Hauterkrankungen) [4-6]
• Haarverlust [4-6]
• Neurodegenerative Erkrankungen [7-9]
• Subfertilität/Infertilität (Unfruchtbarkeit) [10]

Literatur

1. Soda K, Dobashi Y, Kano Y, Tsujinaka S, Konishi F. Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Exp Gerontol. 2009 Nov;44(11):727-32.
2. Gassen N, Papies J, Bajaj T, Dethloff F, Emanuel J, Weckmann K, Heinz DE, Heinemann N, Lennarz M, Richter A, Niemeyer D, Corman VM, Givalisco P, Drosten C, Müller MA. Analysis of SARS-CoV-2-controlled autophagy reveals spermidine, MK-2206, and niclosamide as putative antiviral therapeutics. Nature Communications 2022.
3. Ma L, Ni L, Yang T, Mao P, Huang X, Luo Y, Jiang Z, Hu L, Zhao Y, Fu Z, Ni Y. Preventive and Therapeutic Spermidine Treatment Attenuates Acute Colitis in Mice. J Agric Food Chem. 2021 Feb 17;69(6):1864-1876.
4. Swanson NA, Anderson TF, Duell EA, Voorhees JJ. Decreased urinary polyamines in patients with psoriasis treated with etretinate. J Invest Dermatol. 1983 Mar;80(3):181-4.
5. Einspahr JG, Xu MJ, Warneke J, Saboda K, Ranger-Moore J, Bozzo P, Duckett L, Goldman R, Lin P, Buckmeier J, Alberts DS. Reproducibility and expression of skin biomarkers in sun-damaged skin and actinic keratoses. Cancer Epidemiol Biomarkers Prev. 2006 Oct;15(10):1841-8.
6. Rinaldi F. New multi-targeting strategy in hair growth promotion: in vitro and in vivo studies. G Ital Dermatol Venereol. 2018 Jun;153(3):338-343.
7. Wirth M, Schwarz C, Benson G, Horn N, Buchert R, Lange C, Köbe T, Hetzer S, Maglione M, Michael E, Märschenz S, Mai K, Kopp U, Schmitz D, Grittner U, Sigrist SJ, Stekovic S, Madeo F, Flöel A. Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)-study protocol for a randomized controlled trial. Alzheimers Res Ther. 2019 May 1;11(1):36.
8. Schwarz C, Stekovic S, Wirth M, Benson G, Royer P, Sigrist SJ, Pieber T, Dammbrueck C, Magnes C, Eisenberg T, Pendl T, Bohlken J, Köbe T, Madeo F, Flöel A. Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Aging (Albany NY). 2018 Jan 8;10(1):19-33.
9. Pekar T, Bruckner K, Pauschenwein-Frantsich S, Gschaider A, Oppliger M, Willesberger J, Ungersbäck P, Wendzel A, Kremer A, Flak W, Wantke F, Jarisch R. The positive effect of spermidine in older adults suffering from dementia: First results of a 3-month trial. Wien Klin Wochenschr. 2021 May;133(9-10):484-491.
10. Zhang Y, Bai J, Cui Z, Li Y, Gao Q, Miao Y, Xiong B. Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging. Nat Aging. 2023 Oct 16.